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Sains Malaysiana 54(1)(2025):
225-242
http://doi.org/10.17576/jsm-2025-5401-18
Sequestration of
Doxycycline and Mefenamic Acid from Liquid Phase Using 1,3-Diaminopropane
Modified Poly(Acrylonitrile-Acrylic Acid): Isotherm, Kinetic and Mechanism
Studies
(Penyerapan Doksisiklin dan Asid Mefenamik
daripada Fasa Cecair Menggunakan 1,3-Diaminopropane Poli(Akrilonitril
Asid-Akrilik) Terubah Suai: Kajian Isoterma, Kinetik dan Mekanisme)
FATIMAH
LEE1, SITI NURUL AIN MD JAMIL1,2,*, NUR NIDA SYAMIMI
SUBRI1, ABEL ADEKANMI ADEYI3,4 & RUSLI DAIK5,6
1Department of Chemistry, Faculty of
Science, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia
Diserahkan: 20 Ogos
2024/Diterima: 30 Oktober 2024
Abstract
Accumulation
of pharmaceutical residues in aquatic environment due to daily consumption by
humans and animals for diseases treatment results in alarming long-term
effects. This study evaluates the adsorption potential of a polymer-based
adsorbent, 1,3-diaminopropane-modified poly(acrylonitrile-acrylic acid)
(DAP-poly(ACN/AA)), for the uptake of doxycycline (DOX) and mefenamic acid
(MEFA) from aqueous solution. The chemical modification of poly(ACN/AA)
copolymer with DAP was successful as suggested by the FTIR spectra and
microanalysis results. The SEM analysis showed that the modified copolymer has
larger particle size, which was 156 nm as compared to that of poly(ACN/AA)
copolymer (133 nm). The influence of adsorbent dosage, contact time, pH and
initial concentration on the adsorption of DOX and MEFA compounds were
investigated. The kinetic studies of DOX and MEFA was fitted well to
pseudo-second-order model with chemisorption being the rate-controlling step.
The equilibrium isotherm has its fitness in the following order: Langmuir model
> Freundlich model > Temkin model. The maximum adsorption capacities for
DOX and MEFA were 210.4 mg/g and 313.7 mg/g, respectively. The excellent high
sorption capacity suggest that DAP-modified poly(ACN/AA) copolymer is a
potential adsorbent for the treatment of DOX and MEFA bearing effluent in
adsorption system.
Keywords:
Copolymer; doxycycline; isotherm; kinetic pharmaceutical; mefenamic acid;
poly(acrylonitrile-co-acrylic acid)
Abstrak
Pengumpulan
sisa farmaseutikal dalam persekitaran akuatik akibat penggunaan harian oleh
manusia dan haiwan untuk rawatan penyakit mengakibatkan kesan jangka panjang
yang membimbangkan. Kajian ini menilai potensi penjerapan bahan penjerap
berasaskan polimer, 1,3-diaminopropan-terubahsuai poli(akrilonitril-asid
akrilik) (DAP-poli(ACN/AA)) untuk mengeluarkan doksisiklin (DOX) dan asid
mefenamik (MEFA) daripada larutan akueus. Pengubahsuaian kimia kopolimer
poli(ACN/AA) dengan DAP berjaya seperti mana dicadangkan daripada spektra FT-IR
dan keputusan analisis-mikro. Analisis SEM menunjukkan bahawa kopolimer yang
diubah suai mempunyai saiz zarah yang lebih besar, iaitu 156 nm berbanding
dengan kopolimer poli(ACN/AA) (133 nm). Pengaruh dos penjerap, masa sentuhan,
pH dan kepekatan awal ke atas penjerapan sebatian DOX dan MEFA telah dikaji.
Kajian kinetik DOX dan MEFA telah dipadankan dengan baik pada model pseudo-tertib-kedua
dengan penjerapan kimia sebagai langkah mengawal kadar. Isoterma keseimbangan
mempunyai kesesuaiannya dalam susunan berikut: Model Langmuir > Model
Freundlich > Model Temkin. Kapasiti penjerapan maksimum untuk DOX dan MEFA
masing-masing ialah 210.4 mg/g dan 313.7 mg/g. Kapasiti penjerapan tinggi yang
sangat baik menunjukkan bahawa kopolimer poli(ACN/AA) diubah suai DAP ialah
penjerap yang berpotensi untuk rawatan efluen yang mengandungi DOX dan MEFA
dalam sistem penjerapan.
Kata kunci: Asid
mefenamik; doksisiklina; isoterma; kinetik farmaseutikal; kopolimer;
poli(akrilonitril-ko-asid akrilik)
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